diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-03-25-16-45-31.gh-issue-146427.sbxyZO.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-03-25-16-45-31.gh-issue-146427.sbxyZO.rst
new file mode 100644
index 00000000000000..c1b1e0220be3eb
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-03-25-16-45-31.gh-issue-146427.sbxyZO.rst
@@ -0,0 +1 @@
+Fix a use-after-free in :mod:`!_interpqueues` when clearing items from a destroyed interpreter.
diff --git a/Modules/_interpqueuesmodule.c b/Modules/_interpqueuesmodule.c
index 777b6854749884..c5591f3f35b531 100644
--- a/Modules/_interpqueuesmodule.c
+++ b/Modules/_interpqueuesmodule.c
@@ -763,6 +763,9 @@ _queue_clear_interpreter(_queue *queue, int64_t interpid)
             else {
                 prev->next = next;
             }
+            if (next == NULL) {
+                queue->items.last = prev;
+            }
             queue->items.count -= 1;
         }
         else {